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November 25, 2025The Journal of ImmunologyOpen Access

Lower STAT1 expression by Type I IFN receptor-deficient CD4 T cells responding against Influenza virus cannot account for reduced Th1 hallmarks compared to wildtype CD4 T cells 3138

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Authors

EBEugene BaffoeCFCaroline M FinnKDKunal Dhume

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Overview

Study finds reduced Th1 identity in IFN receptor-deficient CD4 T cells against Influenza virus, suggesting altered immune response.

Key Points

  • The study investigates how cytokine signals influence CD4 T cell responses to Influenza A virus.
  • Compared cytokine responses of WT and IFNAR-/- CD4 T cells in IAV-infected mice.
  • Analyzed Th1 identity and marker expression levels post-infection.
  • Generated STAT1+/- CD4 T cells to assess STAT1 levels' impact on immune response.
  • IFNAR-/- CD4 T cells exhibited reduced Th1 characteristics compared to WT cells.
  • Lower STAT1 levels did not account for weakened Th1 imprint in IFNAR-/- cells.
  • Insights provided on enhancing vaccine-induced antiviral T-cell immunity.

Cite This Study

Baffoe et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac1ea2https://doi.org/10.1093/jimmun/vkaf283.972
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  5. 5Targeted Inhibition of Interferon-γ-dependent Intercellular Adhesion Molecule-1 (ICAM-1) Expression Using Dominant-Negative Stat11997 · 100 citations