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November 25, 2025The Journal of ImmunologyOpen Access

Macrophage repolarization by immune checkpoint blockade drives T-cell engagement in the tumor microenvironment 2076

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Authors

TKTina KwokJLJessica N LancasterHDHaidong Dong

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Overview

Combination immunotherapy improves tumor control by enhancing T-cell activity in the tumor microenvironment, suggesting new treatment strategies.

Key Points

  • This research examines how immune checkpoint blockade affects T-cell and macrophage interactions in tumors.
  • Utilized a murine model of combination anti-PD-1 and anti-PD-L1 checkpoint blockade
  • Monitored monocyte recruitment and differentiation into tumor-associated macrophages
  • Employed live-cell imaging to observe T-cell and macrophage interactions
  • Assessed pro-inflammatory factor expression and phagocytic activity of macrophages
  • Increased infiltration of CD8+ T cells was associated with tumor control
  • M1-like repolarization of tumor-associated macrophages was observed
  • Stable contacts between CD8+ T cells and macrophages were enhanced with combination therapy
  • Anti-PD-L1 treatment boosted macrophage pro-inflammatory expression
  • Co-treatment with anti-PD-1 was critical for achieving tumor control

Cite This Study

Kwok et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac1f37https://doi.org/10.1093/jimmun/vkaf283.041
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