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November 25, 2025The Journal of ImmunologyOpen Access

Inferring B Cell Phylogenies from Paired Heavy and Light Chain BCR Sequences with Dowser 9050

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Authors

CJCole Jensen JSJacob Sumner SKSteven Kleinstein

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Implication

Investigating phylogenetic trees built from paired heavy and light chain sequences, revealing improved accuracy and reproducibility with maximum likelihood methods.

Key Points

To explore strategies for inferring B cell phylogenies from paired heavy and light chain sequences.
Analyzed paired heavy and light chain BCR sequences.
Compared accuracy of phylogenetic trees built using different methods.
Incorporated single-cell sequencing data alongside bulk data.
Incorporating light chains improved tree accuracy and reproducibility.
Maximum likelihood methods were effective in correcting biased branch length estimates.
The benefits of using paired sequences exceeded the variations among tree-building methods.

Cite This Study

Jensen et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac2003 https://doi.org/10.1093/jimmun/vkaf283.2508

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Implication

Investigating phylogenetic trees built from paired heavy and light chain sequences, revealing improved accuracy and reproducibility with maximum likelihood methods.

Inferring B Cell Phylogenies from Paired Heavy and Light Chain BCR Sequences with Dowser 9050

Discussion

Member takes

Implication

Key Points

Cite This Study

Inferring B Cell Phylogenies from Paired Heavy and Light Chain BCR Sequences with Dowser 9050

Discussion

Member takes

Implication

Key Points

Cite This Study

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