What question did this study set out to answer?

This research aims to explore how antigen-presenting cancer-associated fibroblasts influence regulatory T cell function in pancreatic ductal adenocarcinoma.

November 25, 2025The Journal of ImmunologyOpen Access

Antigen-presenting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma differentially regulate Treg phenotype and function via CXCL9 and CCL22 3293

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This research aims to explore how antigen-presenting cancer-associated fibroblasts influence regulatory T cell function in pancreatic ductal adenocarcinoma.
Used KPC murine PDAC model with immunosensitive and resistant tumor clones
Analyzed immune cell infiltration and fibroblast characteristics in tumor microenvironment
Performed imaging mass cytometry and scRNAseq to study interactions and signaling
Immunosensitive tumors showed higher infiltration of antigen-presenting cancer-associated fibroblasts
apCAFs activated and induced Tregs without producing suppressive cytokines
Differential chemokine signaling by apCAFs was linked to Treg differentiation in the tumor microenvironment

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Implication

Findings show antigen-presenting cancer-associated fibroblasts differentially activate Tregs via CXCL9 in pancreatic ductal adenocarcinoma, suggesting targets to improve immune therapy.

Cite This Study

Maru et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac20bd https://doi.org/10.1093/jimmun/vkaf283.1109

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Implication

Findings show antigen-presenting cancer-associated fibroblasts differentially activate Tregs via CXCL9 in pancreatic ductal adenocarcinoma, suggesting targets to improve immune therapy.

Antigen-presenting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma differentially regulate Treg phenotype and function via CXCL9 and CCL22 3293

Key Points

Discussion

Implication

Cite This Study

Antigen-presenting cancer-associated fibroblasts in pancreatic ductal adenocarcinoma differentially regulate Treg phenotype and function via CXCL9 and CCL22 3293

Key Points

Discussion

Implication

Cite This Study

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