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November 25, 2025The Journal of ImmunologyOpen Access

Elevated proportion of circulating T effector memory cells is associated with early disease recurrence in oral squamous cell carcinoma – a case report 3958

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Authors

BBBrianna BrammerBKBrendan KinneyJGJennifer Gross

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Overview

Case report shows elevated T effector memory cells associate with disease recurrence in oral squamous cell carcinoma, suggesting risk factor implications.

Key Points

  • To identify predictive factors for early disease recurrence in oral squamous cell carcinoma.
  • Case report involving two patients with stage 4 OSCC and differing outcomes
  • Clinical evaluation of disease status and treatment history
  • Comparison of circulating T effector memory cells between the patients
  • Nearly half of OSCC patients experience disease recurrence within one year of treatment
  • The 53-year-old patient had 42.8% CD8+ HD TEMRA cells associated with poor outcomes
  • The 86-year-old patient with similar OSCC had only 0.23% CD8+ HD TEMRA cells and no recurrence

Cite This Study

Brammer et al. (2025) studied this question.

synapsesocial.com/papers/692502b787af00ed34ac213dhttps://doi.org/10.1093/jimmun/vkaf283.1699
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