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This research explores the relationship between mRNA subtypes and immune cell infiltration in high-grade serous ovarian cancer.

November 25, 2025The Journal of ImmunologyOpen Access

Transcriptomic subtypes and immune infiltration in high-grade serous ovarian cancer 4644

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Analysis reveals distinct immune infiltration patterns in high-grade serous ovarian cancer, suggesting novel targets.

This research explores the relationship between mRNA subtypes and immune cell infiltration in high-grade serous ovarian cancer.
Analyzed transcriptomic data for four mRNA subtypes: immunoreactive, differentiated, proliferative, and mesenchymal.
Employed DESeq2 and WGCNA to associate gene modules with clinical traits and immune cell types.
Characterized immune landscapes related to each mRNA subtype.
The immunoreactive subtype showed significant enrichment of M1/M2 macrophages and Th1 cells.
Fibroblasts were associated with the mesenchymal subtype.
Proliferative subtype involvement heavily included ovarian stromal cells.

Carey et al. (2025) studied this question.

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