Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 25, 2025The Journal of ImmunologyOpen Access

IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation 2897

View Full Paper
Ask AI
Bookmark
Share

Authors

ZBZarina BruneALAiling LuMMMatthew Moss

Discussion

Loading...

Member takes

Implication

Findings reveal IRF5’s role in glutamine metabolism and T cell responses in experimental autoimmune encephalomyelitis, suggesting therapeutic targeting for multiple sclerosis.

Key Points

  • This research aims to elucidate the role of IRF5 in regulating T cell responses and metabolism following T cell receptor activation.
  • Investigated T cell intrinsic IRF5 regulation of mTORC1 activity.
  • Analyzed metabolic shifts in T cells due to Irf5 loss.
  • Utilized conditional Irf5 knockout mice in a model of experimental autoimmune encephalomyelitis.
  • Demonstrated that IRF5 modulates CD40L protein expression and mTORC1 activity.
  • Identified a shift in glutamine metabolism in T cells linked to Irf5 deletion.
  • Showed that Irf5 knockout mice were protected from clinical signs of EAE.

Cite This Study

Brune et al. (2025) studied this question.

synapsesocial.com/papers/692502be87af00ed34ac228ehttps://doi.org/10.1093/jimmun/vkaf283.761
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IRF5 mediates adaptive immunity via altered glutamine metabolism, mTORC1 signaling and post-transcriptional regulation following T cell receptor activation2024
  2. 2Beyond Transcription: T cell-Intrinsic IRF5 Regulates Metabolism and Post-Transcriptional Responses in Autoimmunity 23097062026
  3. 3The role of IRF5 as an immune regulator2026
  4. 4IRF1 tunes the IRF4—IRF8 axis to drive effector B-cell fates in autoimmunity and inflammaging 22586752026
  5. 5IRF4 controls immune and metabolic signaling with functional effects on the crosstalk between B and T cells 27412025