What question did this study set out to answer?

This research investigates the effects of 4-1BB stimulation on memory B cell formation during Plasmodium infection.

November 25, 2025The Journal of ImmunologyOpen Access

Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection 2954

View Full Paper

Ask AI

Bookmark

Authors

Systemic 4-1BB stimulation improves memory B cell response in Plasmodium-infected mice, indicating immunotherapy potential.

This research investigates the effects of 4-1BB stimulation on memory B cell formation during Plasmodium infection.
Mice underwent systemic 4-1BB stimulation with a monoclonal antibody during Plasmodium infection.
Assessment of memory B cell response and protective effects post-rechallenge.
Transcriptomic and chromatin analysis of memory B cells was performed.
4-1BB stimulation enhanced the formation of extrafollicular memory B cells.
These memory B cells showed superior recall and proliferative capacity.
The protective effects were linked to IFNγ and T-BET-IL-9R signaling.

Calôba et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark