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March 13, 2024The Journal of Immunology

CD4 T Cell–Derived IL-21 Is Critical for Sustaining Plasmodium Infection–Induced Germinal Center Responses and Promoting the Selection of Memory B Cells with Recall Potential

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JJJordan T. JohnsonFSFionna A. SuretteGAGraham Ausdal

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Johnson et al. (2024) studied this question.

synapsesocial.com/papers/68e74353b6db6435876bcb2dhttps://doi.org/10.4049/jimmunol.2300683
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of memory CD4+ T-cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection2024 · 1 citations
  2. 2Early enhanced control of <i>Plasmodium yoelii</i> infection in IL-10-deficient mice is independent of IFN-γ, IL-12, and the humoral response2026
  3. 3IL-15 enhances T resident memory formation and function following genetically attenuated Plasmodium vaccination in mice 32322025
  4. 4Systemic 4-1BB stimulation augments extrafollicular memory B cell formation and recall responses during Plasmodium infection 29542025
  5. 5Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections2026