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November 1, 2025The Journal of ImmunologyOpen Access

IL-15 enhances T resident memory formation and function following genetically attenuated Plasmodium vaccination in mice 3232

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Authors

KBKristina S. BurrackJWJordan WolfordRMRizwan Mahmud

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Overview

Administration of IL-15 improves vaccine efficacy and increases polyclonal immunity in mice against Plasmodium malaria.

Key Points

  • This research aims to evaluate the role of IL-15 in enhancing T resident memory cell formation and immunity following Plasmodium vaccination in mice.
  • Examined IL-15 as an adjuvant in a genetically attenuated Plasmodium vaccine model.
  • Analyzed T cell responses after vaccination and IL-15 treatment in mice.
  • Assessed IL-15 effects on CXCR6+ CD8 and CD4 T cells in the liver.
  • IL-15 treatment increased the number of polyclonal T cells responding to the Plasmodium vaccine.
  • IL-15 enhanced vaccine efficacy post-challenge with Plasmodium sporozoites.
  • Increased production of Plasmodium-specific antibodies was observed.

Cite This Study

Burrack et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3598d0https://doi.org/10.1093/jimmun/vkaf283.1052
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