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November 25, 2025The Journal of ImmunologyOpen Access

Cathepsin-G specific CAR-T cells for the treatment of Acute Myeloid Leukemia 2172

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Authors

TWTara WalhartFSFeifei SongMBMarta Biondi

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Overview

Chimeric antigen receptor targets leukemia cells in models and humanized mice, suggesting antileukemia potential.

Key Points

  • Investigating the clinical potential of Cathepsin-G specific CAR-T cells for treating Acute Myeloid Leukemia (AML).
  • Developed Cathepsin-G specific chimeric antigen receptor (CAR) targeting HLA-A2-restricted CG1 peptide.
  • Enhanced CAR-T cells for improved recognition of low-peptide levels (<0.025 uM).
  • Used AML PDX models and humanized mice for in vivo testing.
  • Enhanced CAR-T cells showed significant antileukemia effects in vitro and in vivo.
  • No hematopoietic toxicity was observed with the CAR-T treatment.
  • Demonstrated faster CD3ζ phosphorylation and robust metabolic profile compared to conventional CAR-T cells.

Cite This Study

Walhart et al. (2025) studied this question.

synapsesocial.com/papers/692502dc87af00ed34ac2baahttps://doi.org/10.1093/jimmun/vkaf283.126
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High-avidity cathepsin-G-specific CAR-T cells for the treatment of acute myeloid leukemia.2026 · 1 citations
  2. 2Immunotherapy targeting a leader sequence cathepsin G-derived peptide2025 · 8 citations
  3. 3Acute Myeloid Leukemia eradication targeting cathepsin g with a dual HLA-restricted TCR2025
  4. 4T cells dressed up with a dual HLA-restricted TCR targeting cathepsin G drive effective AML eradication2026 · 1 citations
  5. 5Development of CAR T cells Targeting a Surface RNA Binding Protein for the Treatment of Acute Leukemias.2026