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November 18, 2025Journal of Clinical MedicineOpen Access

Severe Thrombocytopenia in Pregnancy: Etiology, Management, and Outcomes Across Platelet Count Categories

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Authors

FEFırat ErsanVAVerda AlpayBBBarış Boza

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Overview

Retrospective cohort study assessed outcomes of severe thrombocytopenia in pregnancy, indicating distinct management strategies are needed for different etiologies.

Key Points

  • To determine the etiological distribution and evaluate management strategies and outcomes of severe thrombocytopenia in pregnancy.
  • Retrospective cohort study of 203 pregnant women with severe thrombocytopenia
  • Participants stratified into three groups based on platelet count severity
  • Evaluated demographic characteristics, treatment modalities, and perinatal outcomes.
  • Etiological distribution varied significantly across severity groups (p = 0.001)
  • HELLP syndrome was the most common cause (36.5%) and more prevalent in milder cases
  • Treatment intensity increased with severity, with 79.7% of Group A needing no intervention compared to 26.9% of Group C

Cite This Study

Ersan et al. (2025) studied this question.

synapsesocial.com/papers/692509ddc0ce034ddc3520d5https://doi.org/10.3390/jcm14228162
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Etiological Spectrum and Maternal Peripartum Hematologic Outcomes of Thrombocytopenia in Pregnancy: A Retrospective Cohort Study2026
  2. 2Maternal and fetal outcomes in 151 cases of thrombocytopenia in pregnancy2025 · 3 citations
  3. 3Analysis of Thrombocytopenia in Pregnancy: Etiology, Fetal & Maternal Outcome2024
  4. 4A Study of Thrombocytopenia in Pregnancy-Clinical Characteristics and Outcome in a Tertiary Care Centre2025
  5. 5Thrombocytopenia in Pregnancy: A 5‐Year Analysis of Characteristics and Practices From a Tertiary Academic Center2026