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November 17, 2025Cell Death DiscoveryOpen Access

HMOX1 interacts with BNIP3 to modulate neuronal ferroptosis after spinal cord ischemia-reperfusion injury via a mitophagy-dependent mechanism

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Authors

YDYanni DuanYZYibao ZhangFYFeng-guang Yang

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Overview

Investigation demonstrates that HMOX1 mediates ferroptosis in spinal cord injury, indicating potential therapeutic target mitophagy.

Key Points

  • This research aims to clarify the role of ferroptosis in spinal cord ischemia-reperfusion injury (SCIRI) and the involvement of HMOX1.
  • Examined the interaction of HMOX1 and BNIP3 in neuronal cells after SCIRI.
  • Utilized in vivo and in vitro models to assess the effects of HMOX1 knockdown and overexpression.
  • Investigated the role of mitophagy in mediating ferroptosis in the context of SCIRI.
  • HMOX1 was found to be upregulated following SCIRI.
  • Knockdown of HMOX1 reduced ferroptosis and improved neurological function.
  • HMOX1 interacts with BNIP3 to enhance mitophagy and promote ferroptosis.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/692509ddc0ce034ddc3522ddhttps://doi.org/10.1038/s41420-025-02831-z
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