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October 17, 2025

HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis

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Authors

ISIzadora de SouzaIAIzabela Amélia Marques de AndradeFFFlorêncio Porto Freitas

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Overview

Observational analysis uncovers the role of HMOX1 in modulating ferroptosis in cancer cells, suggesting new therapeutic targets.

Key Points

  • HMOX1 influences ferroptosis sensitivity by modulating intracellular iron levels and signaling pathways.
  • Inactive HMOX1 leads to increased ferritin levels and reduced ferroptosis, indicating a protective role for heme.
  • Targeting the heme/HMOX1/ferritin axis may provide new insights into overcoming apoptosis resistance in cancer therapy.
  • The study demonstrates that manipulating heme metabolism can alter cancer cell fate and sensitivity to cell death.

Cite This Study

Souza et al. (2025) studied this question.

synapsesocial.com/papers/68f199ccde32064e504dd1adhttps://doi.org/10.1101/2025.10.14.682408
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HMOX1 interacts with BNIP3 to modulate neuronal ferroptosis after spinal cord ischemia-reperfusion injury via a mitophagy-dependent mechanism2025
  2. 2HMOX1 regulates ferroptosis via mic14 and its impact on chemotherapy resistance in small-cell lung cancer2024 · 1 citations
  3. 3The Effect of Increased HSF1-HMOX1 Expression in H9C2 Cardiomyocytes Following Hypoxia/Reoxygenation on Myocardial Ferroptosis and M1 Polarization of Macrophages2026
  4. 4Heme Oxygenase‐1 Regulates the JAK/STAT Pathway to Inhibit Ferroptosis in Metabolic Dysfunction‐Associated Steatotic Liver Disease2026
  5. 5Epithelial heme oxygenase-1 enhances colonic tumorigenesis by inhibiting ferroptosis2024 · 1 citations