Demonstrates HMOX1's role in melanoma progression, indicating its potential as a therapeutic target.
BACKGROUND: Melanoma represents a highly aggressive form of skin cancer characterized by significant invasiveness and immune evasion capabilities. Although heme oxygenase-1 (HMOX1) participates in cellular stress responses and ferroptosis, its precise functional roles in melanoma pathogenesis remain incompletely defined. METHODS: effect of HMOX1 knockdown was evaluated using a mouse subcutaneous xenograft model. RESULTS: xenograft experiments corroborated these findings, demonstrating significant tumor growth inhibition upon HMOX1 silencing. CONCLUSION: FOXO3-mediated upregulation of HMOX1 promotes melanoma cell proliferation, invasion, immune escape, and ferroptosis resistance. The FOXO3/HMOX1 axis represents a potential therapeutic target for melanoma treatment.
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Ji et al. (2026) studied this question.
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