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November 14, 2025Advanced BiologyOpen Access

The Paradox of Heme Oxygenase 1: From Cellular Defense to a Tug of War between Cancer Promotion and Prevention

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Authors

SJSidhant JainMRMeenakshi RanaNANilza Angmo

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Overview

Review reveals Hmox1 influences cancer progression, indicating its dual role in modulation of pathology.

Key Points

  • To explore the dual role of Hmox1 in cancer, examining its promotion and prevention effects.
  • Review of previous studies on Hmox1 and its inducers.
  • Analysis of Hmox1's effects on cancer types and metabolic processes.
  • Evaluation of the enzyme's protective roles against cellular damage.
  • Hmox1 shows both cancer-promoting and antitumor roles depending on the context.
  • It modulates inflammation, oxidative stress, and apoptosis in cancer cells.
  • Heme degradation by Hmox1 contributes to tissue injury and iron homeostasis.

Cite This Study

Jain et al. (2025) studied this question.

synapsesocial.com/papers/692519acc0ce034ddc354321https://doi.org/10.1002/adbi.202500390
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