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November 17, 2025Clinical EpigeneticsOpen Access

Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention

Haibo Wu Xinke Zhang Zheng-Yi Zhou Ke-Ming Chen Jierong Chen Chao Ma Jin-Ling Duan Ying Qing Li Jiewei Chen

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Key Points

This research focuses on the role of USP44 in esophageal cancer progression.
Examined the hypermethylation status of USP44.
Investigated the interaction between USP44 and SENP2.
Analyzed the therapeutic potential of targeting this axis in esophageal cancer.
USP44 showed significant deubiquitination activity on SENP2.
The USP44-SENP2 axis was found to be critical for esophageal cancer cell progression.
Targeting USP44 presents a promising therapeutic approach for esophageal cancer patients.

Implication

The USP44-SENP2 axis deubiquitinates proteins, highlighting potential therapeutic targets for esophageal cancer treatment.

Abstract

USP44-SENP2 axis is a pivotal factor in the progression of ESCC, and provides potential therapeutic targets for ESCC patients.

Discussion

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Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/692509ddc0ce034ddc352367 https://doi.org/10.1186/s13148-025-01958-1

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