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November 17, 2025OncogenesisOpen Access

YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5

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Authors

LXLun XuQYQian YuXPXu Peihang

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Implication

Experiments demonstrate YTHDF3 enhances invasion and osteoclast differentiation in breast cancer, indicating novel metabolic pathways in osteolytic metastasis.

Key Points

  • This research investigates the role of YTHDF3 in osteolytic bone metastasis of breast cancer.
  • Assessed YTHDF3 expression in clinical breast cancer samples
  • Examined migration and invasion of breast cancer cells in vitro and in vivo
  • Analyzed osteoclast differentiation and bone destruction
  • Studied regulation of ZEB1 and SMAD5 translation by YTHDF3
  • YTHDF3 promotes migration and invasion capacity of breast cancer cells
  • Lower YTHDF3 levels reduce osteoclast differentiation and bone destruction
  • Enhanced ZEB1 expression contributes to increased transcription of bone morphogenetic protein inhibitors
  • WNT5B expression, regulated by ZEB1, plays a role in the osteolytic process

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/692509e3c0ce034ddc352372https://doi.org/10.1038/s41389-025-00583-0
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Also Consider

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  1. 1YTHDF3 modulates the progression of breast cancer cells by regulating FGF2 through m6A methylation2024 · 5 citations
  2. 2YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR – HIF1α – LHDA Axis2026
  3. 3YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression2026 · 1 citations
  4. 4Association of Expression of YTH‐Domain Family Protein 3 (YTHDF3) With Brain Metastases and Unfavorable Survival in Patients With Stage IV Lung Adenocarcinoma2026
  5. 5YTHDF3 Regulates the Degradation and Stability of m6A‐Enriched Transcripts to Facilitate the Progression of Castration‐Resistant Prostate Cancer2024 · 14 citations