The study finds that engineered allosteric DNA aptamers activate fluorescent properties in nanostructures, indicating potential in synthetic DNA computing.
In this study, a systematic approach is presented for the rational design of synthetic allosteric DNA aptamers. This methodology enables precise control over the allosteric ON–OFF transition in fluorescent DNA aptamers, allowing for the engineering of aptamers with highly tunable fluorescent properties. When combined with toehold‐mediated strand displacement, a series of allosteric aptamers is developed in which the target sequence functions as a specific allosteric modulator. Furthermore, these aptamers are applied in synthetic DNA computing and in the construction of responsive nanostructures that light up upon activation.
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Zhang et al. (2025) studied this question.
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