In vitro and in vivo evidence shows osteoblast differentiation enhances bone formation, indicating a role of Wnt signaling in osteoporosis management.
In mouse and cell models, METTL3 promotes FZD3 expression through m6A modification, activates RUNX1 downstream of the Wnt pathway, stimulates osteoblast formation, prevents osteoclast differentiation, and thereby mitigates osteoporosis-like phenotypes.
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Wang et al. (2025) studied this question.
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