This narrative review shows METTL3's dual role in oral tissue regeneration and malignancy, indicating its potential in stem cell therapy and overcoming chemoresistance.
Key Points
Oral tissue regeneration and malignancy are significantly influenced by METTL3's regulatory functions, highlighting its dual role.
It stabilizes mRNA transcripts like GDF6 and enhances dentinogenesis, pointing to its regenerative potential.
Dysregulated METTL3 is linked to osteogenesis impairment in periodontal cells, worsening disease severity.
Targeting METTL3 with drugs like Oxymatrine may provide new avenues for therapies in both regenerative dentistry and oncology.