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December 8, 2025BloodOpen Access

Targeting METTL3 disrupts oncogenic transcriptional programs and activates immune and apoptotic pathways in Acute Myeloid Leukemia

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Authors

QWQian WangWuhan University

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Implication

Targeting METTL3 disrupts transcriptional programs and activates apoptosis and lipid metabolism pathways in AML.

Key Points

  • The study aims to evaluate the role of METTL3 in Acute Myeloid Leukemia and its potential as a therapeutic target.
  • Human AML MOLM13 cells treated with ZW27941 for 24 hours
  • RNA extraction and RNA-seq conducted
  • Differentially expressed genes analyzed using R packages
  • Gene ontology enrichment analysis performed
  • 534 genes upregulated and 641 genes downregulated after ZW27941 treatment
  • Key genes related to innate immunity and inflammation suppressed
  • Lipid metabolism genes downregulated, indicating disrupted fatty acid synthesis
  • Upregulation of apoptosis and DNA damage repair genes following METTL3 degradation

Cite This Study

Qian Wang (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4f4https://doi.org/10.1182/blood-2025-6764
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The role of m6A RNA methyltransferase METTL3 in drug resistance mechanisms in acute myeloid leukemia2026 · 3 citations
  2. 2Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 m6A modification2025 · 2 citations
  3. 3Targeting the METTL1/m7G axis as a therapeutic strategy in myeloid leukemia2025 · 1 citations
  4. 4Abstract 1162: Revealing the transformative role of METTL13 in human hematopoietic stem cells and progression of pediatric leukemia2026
  5. 5METTL13 Promotes Pre-Leukemic Transformation and the Development of Pediatric Leukemia2025