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September 10, 2025Open Access

METTL13 Promotes Pre-Leukemic Transformation and the Development of Pediatric Leukemia

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Authors

SESabina EnlundKarolinska InstitutetCLChae-Eun LimNational Foundation for Cancer ResearchIHIsabella HoangUniversity of California, San Diego

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Implication

This research reveals that mettl13 significantly influences oncogenic development in pediatric T-ALL, suggesting a critical regulatory link with adenosine deaminase.

Key Points

  • Loss of mettl13 inhibits proliferation and survival in pediatric t-cell acute lymphoblastic leukemia, indicating its oncogenic potential.
  • METTL13 is uniquely upregulated by adenosine deaminase, while other METTL genes are downregulated in hematopoietic stem cells.
  • Knockdown of mettl13 altered gene expression involved in oncogenic development, showcasing its role in malignant transformation.
  • Functional studies confirm mettl13's necessity for T-ALL cell proliferation and survival both in vitro and in vivo.

Cite This Study

Enlund et al. (2025) studied this question.

synapsesocial.com/papers/68c1dda254b1d3bfb60fc6b6https://doi.org/10.1101/2025.08.29.673071
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