Rubisco is slow across the tree of life

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Comprehensive analysis uncovers a slow carbon fixation rate of rubisco across diverse ecosystems, suggesting evolutionary constraints.

Rubisco is shown to be a relatively slow enzyme with carboxylation rates never exceeding 30 reactions per second.
The study is based on a characterization of over 250 rubiscos from bacteria and archaea, expanding the known diversity significantly.
Assessment involved a machine learning model trained on rubisco variants, predicting their catalytic rates effectively.
This research establishes a crucial benchmark for understanding rubisco's kinetics within its extensive phylogenetic diversity.

Pins et al. (2025) studied this question.

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