What type of study is this?

This is a Validation Study study.

What question did this study set out to answer?

This study aims to assess the clinical significance of FAP expression in patients with advanced ccRCC.

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Evaluation reveals FAP as a prognostic biomarker for poor outcomes in advanced ccRCC, indicating resistance to TKIs.

This study aims to assess the clinical significance of FAP expression in patients with advanced ccRCC.
Evaluated a cohort of 137 patients with advanced ccRCC
Performed FAP immunohistochemistry (IHC) on primary tumor specimens
Correlated FAP expression with clinicopathological features and treatment outcomes
Higher FAP expression correlates with advanced histological grade and local invasion
FAP-positive tumors showed shorter disease-free and overall survival
Tumors without FAP expression more likely achieved complete response to TKI therapy

Montes et al. (2025) studied this question.

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