Observational study shows Fluvoxamine raises serum concentrations of clozapine, suggesting dose reduction may improve safety.
Fluvoxamine significantly increases clozapine and norclozapine concentrations, and their ratio. Doses > 25 mg lead to greater fold increases and more variability. Initiation at 25 mg with a 50% clozapine dose reduction is recommended.
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Weringh et al. (2025) studied this question.
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