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This review discusses engineered bacteria as a cancer therapy to enhance targeted treatment outcomes.

November 17, 2025Chinese Medical JournalOpen Access

Engineered bacteria for cancer therapy: Advancements, challenges, and future directions

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Authors

MWMinggui Wang MLMei Liu DWDan Wang

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Implication

Review highlights engineered bacteria's potential in cancer therapy, improving targeted treatment by addressing off-target toxicity and drug resistance.

Key Points

This review discusses engineered bacteria as a cancer therapy to enhance targeted treatment outcomes.
Overview of engineered bacteria in cancer therapy
Analysis of challenges like off-target toxicity and drug resistance
Review of integration with conventional therapies
Insights from clinical trials on tumor-targeting bacteria
Engineered bacteria show potential for targeted therapy and reduced off-target toxicity.
Bacteria can colonize tumor microenvironments, enhancing antitumor immune responses.
Combination with traditional therapies improves treatment efficacy and addresses intratumor heterogeneity.

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Wang et al. (2025) studied this question.

synapsesocial.com/papers/692509e3c0ce034ddc3525d6 https://doi.org/10.1097/cm9.0000000000003807

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Implication

Review highlights engineered bacteria's potential in cancer therapy, improving targeted treatment by addressing off-target toxicity and drug resistance.

Engineered bacteria for cancer therapy: Advancements, challenges, and future directions

Discussion

Member takes

Implication

Key Points

Cite This Study

Engineered bacteria for cancer therapy: Advancements, challenges, and future directions

Discussion

Member takes

Implication

Key Points

Cite This Study

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