CXCR3 Deficiency Alleviates Retinal Ganglion Cell Loss by Regulating Neuron–Astrocyte Communication in a Mouse Model of Glaucoma

Fan Xia; Shuizhen Shi; Erick Palacios; Won Kyu Ju; Hua Liu; Wenbo Zhang

doi:10.1167/iovs.66.14.42

November 17, 2025Investigative Ophthalmology & Visual ScienceOpen Access

CXCR3 Deficiency Alleviates Retinal Ganglion Cell Loss by Regulating Neuron–Astrocyte Communication in a Mouse Model of Glaucoma

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Key Points

This research aims to investigate the role of CXCR3 deficiency in retinal ganglion cell loss during glaucoma.
Utilized a mouse model of glaucoma
Assessed neuron–astrocyte communication
Measured retinal ganglion cell loss
CXCR3 deficiency significantly reduced retinal ganglion cell loss
Enhanced neuron–astrocyte communication observed
Indicates potential for an IOP-independent therapeutic strategy in glaucoma

Implication

Findings reveal CXCR3 deficiency mitigates retinal ganglion cell loss in glaucoma, suggesting a new therapeutic strategy.

Abstract

CXCL10/CXCR3 signaling is a key mediator of RGC loss in glaucoma. Targeting this pathway, along with its upregulated C3/C3aR axis, represents a promising IOP-independent therapeutic strategy for glaucoma.

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Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/692509e8c0ce034ddc352671 https://doi.org/10.1167/iovs.66.14.42

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CXCR3 Deficiency Alleviates Retinal Ganglion Cell Loss by Regulating Neuron–Astrocyte Communication in a Mouse Model of Glaucoma

Key Points

Implication

Abstract

Discussion

Cite This Study

CXCR3 Deficiency Alleviates Retinal Ganglion Cell Loss by Regulating Neuron–Astrocyte Communication in a Mouse Model of Glaucoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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