Single-cell RNA-sequencing reveals a dual differentiation role of progenitors in mouse bone marrow, indicating their contribution to bone and fat formation.
The adult bone marrow houses progenitors for both osteoblasts and adipocytes, but their precise molecular identity remains to be fully elucidated. Previous studies indicate that Lepr + Cxcl12 + bone marrow stromal cells collectively give rise to both osteoblasts and marrow adipocytes, but the high degree of heterogeneity among those cells calls for further delineation of common or lineage-specific progenitors in vivo. Here, by single-cell RNA-sequencing we identify a small subset of bone marrow stromal cells coexpressing Adipoq and Osx, along with other osteogenic or adipogenic genes. The Adipoq + Osx + cells predominantly reside in the endosteal niche. Intersectional genetic fate mapping with Dre and Cre recombinases demonstrates dual differentiation of osteoblasts and adipocytes from the Adipoq + Osx + cells in vivo. The data support the Adipoq + Osx + cells as adipo-osteoprogenitors contributing to bone and fat formation in the adult mouse bone marrow.
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Liao et al. (2025) studied this question.
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