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November 17, 2025Clinical Rehabilitation

Overt Agitation in Patients With Prolonged Disorders of Consciousness: Prevalence, Clinical Characterization and Predictive Value

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Authors

ABAlice BarraAMAlfonso MagliacanoMNMaria Dolores Navarro

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Overview

Retrospective cohort study shows agitation's incidence and diagnostic value in patients with disorders of consciousness, indicating potential recovery.

Key Points

  • This research aims to evaluate the incidence of agitation and its diagnostic and predictive value in patients with prolonged disorders of consciousness.
  • Retrospective observational cohort study design
  • Analyzed data from patients in unresponsive wakefulness state and minimally conscious state
  • Collected demographic and clinical information at admission and 24 months post
  • Utilized various scales including Overt Agitation Severity Scale and Coma Recovery Scale-Revised Index.
  • 119 patients were analyzed; 68.1% exhibited signs of agitation
  • Minimally conscious state patients had higher agitation scores compared to unresponsive wakefulness state
  • Significant correlations found between agitation severity and recovery scales
  • 41 patients emerged from minimally conscious state after 24 months, indicating potential for recovery.

Cite This Study

Barra et al. (2025) studied this question.

synapsesocial.com/papers/692509e8c0ce034ddc3528d3https://doi.org/10.1177/02692155251396014
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