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November 17, 2025PLoS Computational BiologyOpen Access

Benchmarking the predictive capability of human gait simulations

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Authors

MAMaarten AfschriftDKDinant KistemakerMBMaarten Bobbert

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Overview

Observational analysis improves muscle activity and energetics in simulations of gait, suggesting needs for model accuracy.

Key Points

  • Simulations predicted muscle activity with reasonable accuracy, but underestimated metabolic power variation.
  • The body segments were manipulated in various conditions, leading to insights about model limitations.
  • Systematic evaluation of a 3D musculoskeletal model highlights areas for improvement in simulations.
  • Enhancing neural control and optimality criteria may advance the realism of gait simulations.

Cite This Study

Afschrift et al. (2025) studied this question.

synapsesocial.com/papers/692509eec0ce034ddc352947https://doi.org/10.1371/journal.pcbi.1012713
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