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November 17, 2025Analytica—A Journal of Analytical Chemistry and Chemical AnalysisOpen Access

Robust LC–MS/MS Methodology for Low-Level PFAS in Sludge Matrices

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Authors

LPLuoana Florentina PascuVPValentina Andreea PetreVIVasile Ion Iancu

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Overview

Validated methodology reveals accurate PFAS quantification in sewage sludge using LC-MS/MS, indicating environmental monitoring importance.

Key Points

  • To develop and validate a reliable analytical method for detecting PFAS in sludge.
  • Optimized liquid chromatography–tandem mass spectrometry (LC–MS/MS) for 28 PFAS compounds.
  • Used solid–liquid extraction with methanol and cleanup with ferrite and sodium sulfate.
  • Conducted chromatographic separation on an Avantor® ACE® PFAS Delay column with an Agilent MS.
  • Achieved MDL < 0.02 µg/g dry weight for most PFAS compounds.
  • Demonstrated satisfactory precision with RSD < 15% and recoveries between 80-118%.
  • Validated method enhances PFAS detection efficiency in complex sludge matrices.

Cite This Study

Pascu et al. (2025) studied this question.

synapsesocial.com/papers/692509fbc0ce034ddc352fa7https://doi.org/10.3390/analytica6040049
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