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November 17, 2025Angewandte ChemieOpen Access

Triply Responsive Control of Ion Transport with an Artificial Channel Creates a Switchable AND to OR Logic Gate

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Authors

JMJavid Ahmad MallaKFKharina J. FentonABAdinarayana Bellamkonda

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Overview

Synthetic ion channels demonstrate enhanced controllability and ion transport modulation through pH, irradiation, and photoswitches, indicating advances in logic gate design.

Key Points

  • Ion transport is modulated 170-fold by pH, irradiation, and guest addition, creating a versatile system.
  • Control over ten photoswitches is achieved, demonstrating improvements in selectivity and activity.
  • Synthetic ion channels integrate multiple stimuli, such as light and pH, to enhance functionality.
  • New logic gate systems may enable innovative applications in synthetic biology and treatment of channelopathies.

Cite This Study

Malla et al. (2025) studied this question.

synapsesocial.com/papers/692509fbc0ce034ddc352fb1https://doi.org/10.1002/ange.202517444
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