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This case series aims to identify risk factors, clinical presentation, and neurodevelopmental outcomes in term neonates with periventricular haemorrhagic infarction.

November 17, 2025Developmental Medicine & Child NeurologyOpen Access

Neonates born at term with periventricular haemorrhagic infarction: Risk factors and clinical presentation

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Authors

AZAleksandra ZaykovaCharité - Universitätsmedizin Berlin JDJeroen Dudink FGFloris Groenendaal

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Implication

Case series reveals risk factors and seizures in term neonates with periventricular haemorrhagic infarction, highlighting neurodevelopmental outcomes.

Key Points

This case series aims to identify risk factors, clinical presentation, and neurodevelopmental outcomes in term neonates with periventricular haemorrhagic infarction.
Case series of 20 neonates born at term diagnosed with PVHI.
Patient records were reviewed for clinical characteristics and presenting symptoms.
MRI classifications assessed venous subtype involvement, while aEEG evaluated activity and seizures.
Neurodevelopmental outcomes were followed up at a median age of 5 years 10 months.
Most neonates (n = 19) presented with seizures on the second day after birth.
Common anatomical involvement was noted in the caudate vein territory (n = 11).
Prothrombotic genetic mutations were present in 10 out of 11 assessed neonates.
Motor impairment was significantly more prevalent in this population compared to cognitive outcomes.

Cite This Study

Zaykova et al. (2025) studied this question.

synapsesocial.com/papers/692509fbc0ce034ddc35300f https://doi.org/10.1111/dmcn.70055

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Implication

Case series reveals risk factors and seizures in term neonates with periventricular haemorrhagic infarction, highlighting neurodevelopmental outcomes.

Neonates born at term with periventricular haemorrhagic infarction: Risk factors and clinical presentation

Discussion

Member takes

Implication

Key Points

Cite This Study

Neonates born at term with periventricular haemorrhagic infarction: Risk factors and clinical presentation

Discussion

Member takes

Implication

Key Points

Cite This Study

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