Optimized triplex nanomaterial all-around gate tunnel field-effect transistors for high-precision biomolecule detection

In this present work, a biosensor built upon the triplex nanomaterial all-around gate tunnel field-effect transistor (TFET) is proposed concerning biomolecule detection. This design leverages an advanced all-around gate structure, enhancing sensitivity and selectivity in biosensing applications. Field-effect transistor (FET) biosensors offer portability and rapid, high-throughput screening capabilities, which make them particularly suitable for detecting biomarkers. The proposed 3MAG TFET biosensor includes precisely engineered nanocavities over a 1 nm gate oxide, designed to capture and detect target biomolecules efficiently. To investigate its performance, a two-dimensional simulation is conducted using technology computer-aided design (TCAD) software, enabling thorough parameter exploration. The triplex material composition contributes to low power consumption and high device sensitivity, making the biosensor a promising candidate for various biomolecular detection applications. Analytical insights were derived and validated through Sentaurus TCAD simulation results. The proposed device exhibits distinct electrical responses to biomolecules of different dielectric constants and charge states, such as DNA and proteins. Selective detection can be realized through receptor functionalization of the nanocavity surface.