Analysis shows rising trends in lower extremity peripheral arterial disease, highlighting interventions may reduce mortality and improve healthcare access.
LEPAD imposes a substantial global burden, disproportionately affecting females and populations in low-resource settings. Modifiable metabolic (glucose, kidney function, BMI, hypertension) and behavioral (smoking) risks dominate. Targeted interventions, especially in high-burden regions experiencing increasing trends, are urgently needed to mitigate LEPAD-related morbidity and mortality. Future research should focus on effective interventions and healthcare access barriers.
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Zhang et al. (2025) studied this question.
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