Key result
Global LEPAD cases among postmenopausal women increased ~100% from 1990 to 2021.
Why the study?
To comprehensively analyze the global burden and attributable risk factors for lower extremity peripheral arterial disease among postmenopausal women, and project future trends.
Observational
The absolute global burden of lower extremity peripheral arterial disease among postmenopausal women has significantly increased from 1990 to 2021, driven by population growth and aging, highlighting the need for targeted prevention strategies.
May support heightened clinical vigilance for LEPAD in postmenopausal women; leaves open sex-specific prevention trials.
Purpose: This study aimed to conduct a comprehensive analysis of the global burden and attributable risk factors for lower extremity peripheral arterial disease (LEPAD) among postmenopausal women, and project future trends. Methods: All data were obtained from the Global Burden of Disease Study 2021, stratified by age, sex, and region to evaluate disparities. We performed decomposition analysis to quantify the contributions of population growth, aging, and epidemiological changes, and comparative risk assessment to evaluate attributable risk factors. The Bayesian age-period-cohort (BAPC) model was applied to project future trends by 2035. Results: In 2021, there were 66,392,811 prevalent cases, 33,854 deaths, and 777,299 DALYs of LEPAD among postmenopausal women globally. Due to population growth and aging, these figures increased by 99.84%, 72.93%, and 73.06%, respectively, compared to 1990. High fasting plasma glucose was the leading attributable risk factor. Projections indicate a continued increase in the global burden by 2035. Conclusion: Our findings reveal a substantial and persistently increasing burden of LEPAD among postmenopausal women globally. Targeted strategies are urgently needed to ensure healthier aging among this vulnerable population.
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Yuan et al. (2026) conducted an observational in Lower extremity peripheral arterial disease. Global prevalent cases of lower extremity peripheral arterial disease among postmenopausal women increased by 99.84% from 1990 to 2021, reaching 66,392,811 cases.
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