Morin alleviates sepsis-associated encephalopathy through inhibiting ferroptosis via SIRT1

November 16, 2025Brain Research BulletinOpen Access

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Key Points

To evaluate the effect of Morin on sepsis-associated encephalopathy and its mechanism of action.
In vitro and in vivo experiments assessing Morin's impact on SAE
Measurement of ferroptosis levels
Analysis of SIRT1 involvement in the neuroprotective effects of Morin.
Morin significantly reduced markers of ferroptosis in models of SAE
SIRT1 was identified as a key mediator in the neuroprotective effects of Morin
The intervention improved cognitive outcomes in sepsis-related encephalopathy.

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Findings reveal Morin reduces ferroptosis in sepsis-associated encephalopathy, suggesting neuroprotective potential in critical illness.

Morin alleviates SAE by inhibiting ferroptosis via SIRT1.

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Wu et al. (2025) studied this question.

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