Genome mining reveals trichobisabolin B forms from farnesyl pyrophosphate via Cytochrome P450 and terpene cyclase, indicating a novel biosynthetic route.
Through genome mining, a conserved biosynthetic gene cluster from the biocontrol Trichoderma species was identified and characterized to be responsible for the biosynthesis of γ-butenolide-containing sesquiterpenoid trichobisabolin B. The biosynthetic pathway involves a UbiA-type terpene cyclase TbaA catalyzing the cyclization of farnesyl pyrophosphate to form (3S,6R,7S)-zingiberenol, a stink bug pheromone, and a multifunctional cytochrome P450 TbaB catalyzing the sequential oxidation on an isoprene unit of zingiberenol to generate the γ-butenolide moiety.
No takes yet. Share an insight, caveat, or question.
Shen et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: