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November 15, 2025Annals of Gastroenterological SurgeryOpen Access

Risk Factors for Body Weight Loss After Gastrectomy for Gastric Cancer Analyzed From the JCOG1001 Phase III Trial

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Authors

TYTakanobu YamadaYKYukinori KurokawaJMJunki Mizusawa

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Overview

Post hoc analysis identifies high BMI, total gastrectomy, and complications as risk factors for body weight loss in gastric cancer patients.

Key Points

  • To identify factors associated with body weight loss after gastrectomy for gastric cancer.
  • Post hoc analysis of 728 patients from the JCOG1001 trial
  • Comparison of background, surgery, and postoperative data between patients with and without significant body weight loss
  • Logistic regression analysis to evaluate the impact of different factors on body weight loss
  • 35.4% of patients experienced body weight loss ≥ 10% after surgery
  • Independent risk factors included preoperative BMI ≥ 25, total gastrectomy, and grade 2–4 postoperative complications
  • Multivariable analysis showed significant odds ratios for identified risk factors

Cite This Study

Yamada et al. (2025) studied this question.

synapsesocial.com/papers/6925198ec0ce034ddc3535fahttps://doi.org/10.1002/ags3.70123
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