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November 15, 2025Applied Biological ChemistryOpen Access

Effects of brown algae (Sargassum thunbergii and Sargassum fusiforme) on the progression of some characteristics of alzheimer’s disease and microglial dysfunction in D-galactose-induced aging rat

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Authors

KPKitipong PromyoACA-Ra ChoDSDo-Young Song

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Overview

Experimental study shows brown algae improve memory and cognitive impairment in aging rats, suggesting benefits for Alzheimer’s disease.

Key Points

  • This research aims to assess the potential protective effects of brown algae on Alzheimer's disease characteristics and microglial dysfunction in aging rats.
  • Administered D-galactose (150 mg/kg, i.p.) to induce aging in Sprague Dawley rats.
  • Tested hot water extract of Sargassum thunbergii and Sargassum fusiforme at varying doses.
  • Monitored improvements in memory and cognitive function via radial arm maze and novel object recognition tests for 13 weeks.
  • Brown algae treatments improved memory and cognitive function in aging rats.
  • Significant reductions in amyloid beta levels and oxidative stress observed with Sargassum treatments.
  • Only Sargassum thunbergii reduced hyper-phosphorylated tau proteins linked to Alzheimer’s disease.

Cite This Study

Promyo et al. (2025) studied this question.

synapsesocial.com/papers/6925198ec0ce034ddc353672https://doi.org/10.1186/s13765-025-01054-1
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Also Consider

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