Case evaluations reveal challenges of distinguishing light-chain hematogones from B-cell lymphoma, indicating critical diagnostic considerations.
Background and Objective: The aim is to differentiate light-chain-restricted hematogones (LCR-HGs) from B-cell lymphoma. Materials and Methods: We identified eight patients who underwent bone marrow (BM) flow cytometry (FLC) diagnosis or evaluation for lymphoma/multiple myeloma. Results: Among the eight cases, there are two chronic lymphocytic leukemia, one marginal zone lymphoma, one mantle cell lymphoma, one multiple myeloma, one hepar diffuse large B-cell lymphoma, and one monomorphic epitheliotropic intestinal T-cell lymphoma, in whom FLC immunophenotypes of BM-aspirated specimens showed LCR-HGs. Conclusion: Failure to recognize LCR-HGs and diagnostic test interference associated with antibody-based therapies leads to erroneous diagnosis.
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Yang et al. (2025) studied this question.
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