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December 8, 2025BloodOpen Access

Clinicopathological characteristics of high-grade B-cell lymphomas through  Bone marrow evaluation

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Authors

XLXiaoyan Li

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Overview

Retrospective analysis identified blastoid features and anemia in high-grade B-cell lymphoma cases, suggesting critical diagnostics.

Key Points

  • This research aims to explore the clinicopathological features and diagnostic criteria for high-grade B-cell lymphoma detected through bone marrow evaluation.
  • Conducted a retrospective analysis on 23 cases of high-grade B-cell lymphoma.
  • Classified cases based on the 2022 WHO Classification, examining morphology and immunophenotyping.
  • Performed cytogenetic analysis and assessed immunophenotypic characteristics.
  • Found that 91% of cases exhibited a diffuse pattern of bone marrow involvement.
  • Anemia was present in 65% and leukocytosis in 57% of cases.
  • Noted that 87% of cases showed a GCB phenotype, with some cases challenging to differentiate from B-acute lymphoblastic leukemia.

Cite This Study

Xiaoyan Li (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de26https://doi.org/10.1182/blood-2025-5453
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