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June 20, 2026BiomedicinesOpen Access

Clinical and Pathological Features That Predict High-Grade B-Cell Lymphomas (HGBCLs) with MYC and BCL2 or BCL6 Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis

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Authors

ELErnest LeeWWWai Ying Katherine WongHYHan-Chieh Yang

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Overview

Systematic review identifies features predicting double-hit lymphoma in high-grade B-cell lymphomas, indicating aggressive treatment need.

Key Points

  • The aim was to identify clinicopathological features that differentiate double-hit lymphomas from non-double-hit high-grade B-cell lymphomas.
  • Conducted a PRISMA systematic review and meta-analysis on 29 studies from multiple databases.
  • Calculated risk ratios to compare features between double-hit and non-double-hit high-grade B-cell lymphomas.
  • Examined features such as Ann Arbor stage, International Prognostic Index, and immunophenotypes.
  • DHL patients exhibited higher Ann Arbor stage (RR 1.15, p=0.028) and IPI score (RR 1.27, p=0.047).
  • Elevated lactate dehydrogenase levels were associated with DHL (RR 1.26, p=0.012).
  • Germinal center B-cell-like immunophenotype was significantly predictive for MYC/BCL2 DHL (RR 1.21, p=0.043).

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/6a36306fdb0793dc1a5378f1https://doi.org/10.3390/biomedicines14061375
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and Pathological Features that Predict High-Grade B-Cell Lymphomas (HGBCLs) with MYC and BCL2 or BCL6 Translocations (Double-Hit Lymphoma): A Systematic Review and Meta-Analysis2026
  2. 2Molecular Profiling of High-Grade B-Cell Non-Hodgkin Lymphomas and Its Clinicopathologic Correlation in an Indian Tertiary Cancer Care Center2024 · 1 citations
  3. 3Evaluation of Immunohistochemical Expression of C-MYC, BCL2, and BCL6 in High Grade B-cell Lymphoma2026
  4. 4Clinical outcomes, patterns of relapse and molecular landscape of advanced stage High Grade B-cell Lymphoma2026
  5. 5Clinicopathological characteristics of high-grade B-cell lymphomas through  Bone marrow evaluation2025