MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway

Qi Zhang; Li Chen; Jun-Yan Liu; Tao Liu; Rui Wang; Xin-Yi Wu; Sheng-wei Li

doi:10.1186/s12967-025-07302-8

November 14, 2025Journal of Translational MedicineOpen Access

MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway

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Key Points

The research aims to explore how Ox-mtDNA affects macrophage pyroptosis and MASH progression.
Investigated the role of Ox-mtDNA in macrophage pyroptosis.
Examined the ITPR3/Ca2+/NLRP3 pathway in the context of MASH.
Conducted in vitro and in vivo experiments to assess outcomes.
Ox-mtDNA was found to promote macrophage pyroptosis.
MPTP exposure increased the severity of MASH symptoms.
Activation of the ITPR3/Ca2+/NLRP3 pathway was implicated in this process.

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Implication

Research finds Ox-mtDNA exacerbates MASH by inducing macrophage pyroptosis, suggesting new therapeutic strategies.

Abstract

This study demonstrates that Ox-mtDNA drives MASH progression by promoting macrophage pyroptosis via the ITPR3/Ca²⁺/NLRP3 axis, providing a novel therapeutic strategy for targeted intervention.

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc3539ad https://doi.org/10.1186/s12967-025-07302-8

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MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

MPTP mediated Ox-mtDNA release inducing macrophage pyroptosis and exacerbating MCD-induced MASH via promoting the ITPR3/Ca2+/NLRP3 pathway

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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