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November 14, 2025Translational Vision Science & TechnologyOpen Access

Effects of Benzalkonium Chloride, a Preservative in Topical Drugs, on the Barrier Function of Human Corneal Epithelial Cells

Xiang Zheng Mohamed Shawky Diego G. Ogando Miho Nishiyama Ahmed S. Ibrahim Sangly P Srinivas Xiang Zheng Mohamed Shawky Diego G. Ogando Miho Nishiyama Ahmed S. Ibrahim Sangly P Srinivas

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Key Points

This research assesses the effects of Benzalkonium Chloride on the barrier function of human corneal epithelial cells.
Conducted real-time impedance assessments of cell barriers.
Evaluated mitochondrial functionality in response to Benzalkonium Chloride exposure.
Determined toxicity thresholds for BAK to inform formulation development.
Benzalkonium Chloride was found to compromise the barrier function of corneal epithelial cells.
Real-time assessments provided critical thresholds for BAK toxicity on ocular surface cells.
Findings support the need for reformulating topical drugs to enhance ocular protection.

Implication

Real-time impedance reveals BAK toxicity effects on barrier function in corneal cells, indicating safer drug formulations.

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Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc3539f8 https://doi.org/10.1167/tvst.14.11.16

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Investigation of Corneal Epithelial Tight Junction Disruption and Barrier Function Impairment Induced by Benzalkonium ChlorideOriginal Research · 2026
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