Visceral lipid accumulation and lipid accumulation product outperform insulin resistance score for metabolic syndrome prediction in Northern Chinese adults: validation through AUC comparison and decision curve analysis

Qing Liu; Xing Guan; Li-Jun Wang; Zheng Wang; Han Zhang; Yu Qiang Zuo

doi:10.1186/s12902-025-02086-w

November 14, 2025BMC Endocrine DisordersOpen Access

Visceral lipid accumulation and lipid accumulation product outperform insulin resistance score for metabolic syndrome prediction in Northern Chinese adults: validation through AUC comparison and decision curve analysis

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Key Points

This research aims to compare the effectiveness of lipid accumulation measures with insulin resistance score in predicting metabolic syndrome (MetS).
Conducted large-scale validation study in Northern Chinese adults.
Compared lipid accumulation product (LAP) and visceral adiposity index (VAI) with insulin resistance score (METS-IR).
Utilized AUC comparison and decision curve analysis to assess predictive performance.
LAP and VAI identified as superior predictors of metabolic syndrome.
LAP is the optimal predictor overall and for women, while VAI excels in men.

Implication

Validation shows risk stratification by lipid accumulation product and visceral lipid accumulation improves metabolic syndrome prediction.

Abstract

This large-scale validation establishes LAP and VAI as superior, sex-specific predictors of MetS compared to METS-IR. LAP is optimal overall and in women, while VAI is optimal in men. Their reliance on standard clinical measurements establishes them as practical tools for metabolic risk stratification.

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Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc353a35 https://doi.org/10.1186/s12902-025-02086-w

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Visceral lipid accumulation and lipid accumulation product outperform insulin resistance score for metabolic syndrome prediction in Northern Chinese adults: validation through AUC comparison and decision curve analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Visceral lipid accumulation and lipid accumulation product outperform insulin resistance score for metabolic syndrome prediction in Northern Chinese adults: validation through AUC comparison and decision curve analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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