Prognostic scores for patients with multiple brain metastases treated with repeated stereotactic radiosurgery − a secondary analysis of the CYBER-SPACE randomized phase 2 trial

Q: What type of study is this?

This is a Human Clinical Trial study (also classified as: Phase 2, Validation Study).

Annabella Schiele; Denise Bernhardt; Thomas Welzel; Paul Thalmann; Laila König; Tanja Eichkorn; Anna Kramer; Kristin Lang; Adriane Lentz-Hommertgen; Fabian Weykamp; Farastuk Bozorgmehr; Michael Thomas; Anja Sander; Stefan Rieken; Jürgen Debus; Rami A. El-Shafie

doi:10.1016/j.radonc.2025.111279

November 14, 2025Radiotherapy and OncologyOpen Access

Prognostic scores for patients with multiple brain metastases treated with repeated stereotactic radiosurgery − a secondary analysis of the CYBER-SPACE randomized phase 2 trial

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Key Points

To evaluate the effectiveness of prognostic scores in predicting treatment outcomes for brain metastases after stereotactic radiosurgery.
Performed secondary analysis of the CYBER-SPACE randomized phase 2 trial.
Analyzed prognostic scores with a focus on their predictive capability for overall survival and WBRT.
Identified distinct BMV cut-offs to aid clinical decision-making regarding treatment options.
BMV was the only score predictive of both overall survival (OS) and WBRTi across all tumor types.
Identified two specific BMV cut-offs that may guide decisions between continued SRS and early WBRT.
Findings suggest a need for further external validation of these cut-offs to confirm efficacy.

Implication

Secondary analysis of CYBER-SPACE trial shows prognostic scores impact treatment choices for brain metastases, highlighting survival outcomes.

Abstract

BMV was the only score able to predict both OS and WBRTi across all tumor types. Two distinct endpoint-specific BMV cut-offs may support clinical decision-making between continued SRS and early WBRT, but warrant further external validation.

Discussion

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Cite This Study

Schiele et al. (2025) studied this question.

synapsesocial.com/papers/692519a2c0ce034ddc353c88 https://doi.org/10.1016/j.radonc.2025.111279

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Prognostic scores for patients with multiple brain metastases treated with repeated stereotactic radiosurgery − a secondary analysis of the CYBER-SPACE randomized phase 2 trial

Key Points

Implication

Abstract

Discussion

Cite This Study

Prognostic scores for patients with multiple brain metastases treated with repeated stereotactic radiosurgery − a secondary analysis of the CYBER-SPACE randomized phase 2 trial

Key Points

Implication

Abstract

Discussion

Cite This Study

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