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November 14, 2025Investigative Ophthalmology & Visual ScienceOpen Access

Central Corneal Epithelial Wounding Accelerates Aniridia-Associated Keratopathy in PAX6-Deficient Mice

Yedizza Rautavaara Israa Sefawi Meri Vattulainen Petros Moustardas Dina Javidjam Ava Dashti Neil Lagali Yedizza Rautavaara Israa Sefawi Meri Vattulainen Petros Moustardas Dina Javidjam Ava Dashti Neil Lagali

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Abstract

Central epithelial wounding accelerates AAK progression in Sey mice, highlighting the epithelial fragility in Pax6-aniridia and providing an efficient and robust accelerated model of AAK progression for preclinical studies.

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Cite This Study

Rautavaara et al. (2025) studied this question.

synapsesocial.com/papers/692519a2c0ce034ddc353c94 https://doi.org/10.1167/iovs.66.14.33

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targetsReview · 2026 · 3 citations
2Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse ModelOriginal Research · 2026
3Aniridia: current pathology and managementOriginal Research · 2008 · 262 citations
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