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November 14, 2025Journal of Gastroenterology and Hepatology

Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer

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Authors

HWHao WangRJRongrong JiangCLCaitang Liu

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Overview

In vitro and in vivo findings show narirutin inhibits tumorigenesis and fatty acid metabolism in colorectal cancer, indicating its potential as a chemopreventive agent.

Key Points

  • The research aims to investigate the effects of narirutin on colorectal cancer and its underlying mechanisms.
  • Performed flow cytometry, xenograft models, and various cellular assays to evaluate the effects of narirutin.
  • Assessed lipid accumulation and fatty acid metabolism in colorectal cancer cells after narirutin treatment.
  • Conducted network pharmacology analysis and molecular docking to identify narirutin's targets.
  • Measured protein changes involved in proliferation, apoptosis, and fatty acid metabolism using western blot techniques.
  • Narirutin reduced CRC cell proliferation, migration, and invasion while inducing apoptosis.
  • In vivo studies showed that narirutin inhibited tumor growth and affected related protein levels.
  • Narirutin directly targeted and downregulated ADORA3 expression, impacting tumorigenesis and fatty acid metabolism.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/692519a2c0ce034ddc353dc8https://doi.org/10.1111/jgh.70165
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Also Consider

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